CVE-2024-50623 can be exploited by an unauthenticated attacker to gain remote code execution on affected Cleo servers. Widespread exploitation has been observed. The vendor's advisory page is available here.
John Hammond at Huntress has released a technical article regarding this vulnerability, including a list of IOC's from live attacks in the wild. Originally it was believed that this patch was insufficient in fixing this CVE, due to ongoing exploitation against patched hosts. However, it seems that there is a second unauthenticated remote code execution vulnerability which does not carry a CVE currently. Further details regarding this unknown CVE can be found here.